Table 3.
Non-RP Human Genes That Have the Largest Number of Processed Pseudogenes
| Accession numbera | No. of ψG | Ave. seq. identityb | Protein lengthc | GC contentd | Description |
|---|---|---|---|---|---|
| Q9H0E0 | 73 | 55% (73%) | 129 | 0.59 | Hypothetical 13.4 kD protein |
| P05092 (CYPH_HUMAN) | 63 | 81% (90%) | 164 | 0.49 | Peptidyl-prolyl cis–trans isomerase A, cyclophilin A |
| P05783 (K1CR_HUMAN) | 61 | 82% (91%) | 429 | 0.58 | Keratin, type I cytoskeletal 18 |
| Q9H387 | 58 | 71% (84%) | 118 | 0.49 | PRO2550 |
| O95662 | 54 | 77% (87%) | 194 | 0.56 | Pot. ORF VI (fragment) |
| P04406 (G3P2_HUMAN) | 52 | 74% (85%) | 334 | 0.55 | Glyceraldehyde-3-phosphate dehydrogenase, GAPDH |
| P09651 (ROA1_HUMAN) | 50 | 74% (91%) | 371 | 0.48 | Heterogeneous nuclear ribonucleoprotein A1 |
| Q96C64 | 48 | 82% (92%) | 97 | 0.43 | Hypothetical protein XP_086278 |
| O00369 | 36 | 66% (80%) | 338 | 0.43 | P40 |
| P06748 (NPM_HUMAN) | 34 | 84% (93%) | 294 | 0.42 | Nucleophosmin |
| Q96N32 | 33 | 76% (89%) | 168 | 0.40 | CDNA FLJ31471 fis, clone NT2NE2001435 |
| Q9P2Y3 | 32 | 45% (68%) | 286 | 0.39 | Nef attachable protein |
| P00001 (CYC_HUMAN) | 31 | 75% (88%) | 104 | 0.44 | Cytochrome c |
| Q9H6U5 | 31 | 42% (62%) | 132 | 0.52 | CDNA: FLJ21858 fis, clone HEP02301 |
| P05787 (K2C8_HUMAN) | 31 | 81% (90%) | 482 | 0.59 | Keratin, type II cytoskeletal 8 |
| Q14288 | 26 | 79% (87%) | 641 | 0.40 | Hypothetical 75.3-kD protein (fragment) |
| P06351 (H33_HUMAN) | 25 | 76% (86%) | 135 | 0.52 | Histone H3.3 |
| Q96NR6 | 22 | 66% (81%) | 136 | 0.51 | CDNA FLJ30278 fis, clone BRACE2002755 |
| Q15369 | 21 | 64% (80%) | 112 | 0.42 | RNA polymerase II elongation factor SIII, p15 subunit |
| Q04984 (CH10_HUMAN) | 20 | 78% (89%) | 101 | 0.42 | 10-kD heat-shock protein, mitochondrial |
| P04720 (EF11_HUMAN) | 20 | 83% (91%) | 462 | 0.48 | Elongation factor 1-α1 |
| P02794 (FRIH_HUMAN) | 20 | 77% (87%) | 182 | 0.49 | Ferrotom heavy chain |
| Q9P195 | 20 | 67% (81%) | 118 | 0.49 | PRO1722 |
| P35232 (PHB_HUMAN) | 20 | 75% (87%) | 272 | 0.56 | Prohibitin |
| Q9Y4M8 | 20 | 51% (71%) | 146 | 0.66 | Hypothetical 16.0-kD protein |
| Q9NSI7 | 19 | 65% (82%) | 136 | 0.42 | PRED15 protein (fragment) |
| P55855 (SM32_HUMAN) | 19 | 78% (89%) | 95 | 0.45 | Ubiquitin-like protein SMT3B |
| Q9P1R1 | 19 | 85% (92%) | 240 | 0.46 | Putative taste receptor HTR2 (fragment) |
| Q9NSV3 | 19 | 70% (85%) | 228 | 0.61 | Hypothetical 24.3-kD protein (fragment) |
| Q15357 (RUXG_HUMAN) | 18 | 80% (90%) | 76 | 0.40 | Small nuclear ribonucleoprotein G |
| Q14287 | 17 | 60% (74%) | 157 | 0.40 | Hypothetical 18.5-kD protein (fragment) |
| Q9UN81 | 17 | 83% (91%) | 338 | 0.42 | Hypothetical 40.1-kD protein |
| P02571 (ACTG_HUMAN) | 17 | 79% (86%) | 375 | 0.61 | Actin, cytoplasmic 2 |
| O00483 (NUML_HUMAN) | 16 | 73% (88%) | 81 | 0.47 | NADH-ubiquinone oxidoreductase MLRQ subunit |
| P09669 (COXH_HUMAN) | 16 | 65% (82%) | 75 | 0.47 | Cytochrome c oxidase polypeptide VIc precursor |
| P26583 (HMG2_HUMAN) | 15 | 65% (71%) | 208 | 0.47 | High mobility group protein 2 |
| Q16465 (YZA1_HUMAN) | 15 | 81% (92%) | 122 | 0.51 | Hypothetical protein (fragment) |
| P02570 (ACTB_HUMAN) | 15 | 75% (84%) | 375 | 0.61 | Actin, cytoplasmic 1 |
| Q9UFZ2 | 14 | 76% (87%) | 93 | 0.44 | Hypothetical 10.1-kD protein |
| P50502 (ST13_HUMAN) | 14 | 87% (94%) | 369 | 0.47 | Hsc70-interacting protein |
a
Accession numbers and entry names in the SWISS-PROT/TrEMBL for the functional human proteins. Only those proteins that are in SWISS-PROT have entry names, as shown in the parentheses
b
Average amino acid and nucleotide (in parentheses) sequence identities between the pseudogenes and the functional genes
c
Number of amino acids in the functional protein
d
GC content of the protein-coding sequence (CDS) of the functional gene