Table 1.

Characteristics of the disease and the patients with refAML and refAML

	Primary refractory AML (n = 16)	First relapse AML (n = 62)
Age	1.2–17.1 years (median 12.7)	0.1–17.5 years (median 10.9)
Risk group at primary diagnosis  SR  HR	16 (100%)	17 (27%) 45 (72%)
Initial protocol  AML-BFM 2004 Interim  ANLL98	15	53 9
Site of primary disease/relapse  isolated BM  BM + CNS  BM + other  isolated CNS  other isolated	13 2 1	43 10 4 4 1