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. Author manuscript; available in PMC: 2014 May 29.
Published in final edited form as: Hippocampus. 2012 Sep 11;23(1):108–115. doi: 10.1002/hipo.22068

Figure 2. E2-enhanced NOR is prevented by blocking NR2B-containing NMDARs.

Figure 2

A1. Experimental timeline. A2. No object preference during training. A3. Systemic RO (5mg/kg) blocks learning and memory in E2-treated animals only. B1. Experimental timeline for intraCA1 infusion of RO. B2. No object preference during training. B3. IntraCA1 RO (0.375µg/1µL) infusion blocks E2-enhanced learning and memory. Importantly, V-treated animals still spend significantly more time on the novel object compared to chance. C. Cannula tip locations for each animal included in behavioral experiments. Inset: Cresyl violet stained hippocampal brain slice showing representative cannula tip placement. Scale bar represents 100µM. D. Infusion of 3.75µg/1µL RO blocks NOR in V-treated animals. + indicates percent time spent on novel object is significant from chance. *p<0.05 comparing E2 Sal and E2 RO.