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. Author manuscript; available in PMC: 2014 May 29.
Published in final edited form as: J Immunol. 2010 Dec 6;186(1):621–631. doi: 10.4049/jimmunol.1002230

FIGURE 1.

FIGURE 1

Glomerular inflammation in PPARγ-KO and RXRα-KO mice. A, Glomerular angioarchitecture was analyzed by OPT. Arrowheads indicate enlarged glomeruli. Scale bar, 2 mm. B, H&E- and PAS-stained sections of the renal cortex. Arrowheads show thickened capillary walls. Scale bar, 30 μm. C, Histomorphometric analysis was performed on kidney sections of 4–6-mo-old WT, PPARγ-KO, and RXRα-KO mice. Data are means ± SEM from six mice per genotype. Plasma creatinine levels and albumin content in pooled urine collected over 24 h are expressed as mean values ± SEM from four mice per genotype. *p < 0.05; **p < 0.01. D, Top, Silver impregnation of kidney sections from 4–6-mo-old mice. Arrowheads indicate basement membranes. Scale bar, 20 μm. Bottom, Transmission electron microscopy (TEM) analysis of the glomerular walls in 4–6-mo-old mice. Thickening (arrows) and fusions (white arrowheads) of the podocyte (pdc) foot processes are visible in PPARγ-KO and RXRα-KO mice. Accumulation of electrolucent material in podocyte processes (asterisks) and a moderate thickening of glomerular basement membrane (bm) are also evident. Black arrowheads label endothelial cells. Scale bar, 0.1 μm.