Table 1.

Human Genome Top 10 Gene-Dense Regions

GoldenPath location	Region	%GC	% repeats	Genes/Mb	Comments
chr6:31250001—32500000	HLAC—HLADRB3	47	47	48.8	Includes MHC class III region
chr6:25500001—26500000	FLJ20048—BTN2A3	41	43	44.0	Includes histone families
chr12:6250001—7250000	FLJ10665—PXR1	46	41	43.1	Includes CD4, complement 1
chr17:39000001—40000000	KRT23—ACLY	46	44	43.0	Includes keratin families
chr19:53250001—55000000	ELSPBP1—TCBAP0758	52	57	42.3	Includes CD37
chr16:250001—1500000	DKFZP761D0211—KIAA0683	60	28	40.8	GC rich
chr11:250001—1500000	AP2A2—HCCA2	53	36	40.2	Gap in sequence; includes IRF7, TOLLIP
chr17:7000001—8000000	ASGR1—PER1	51	43	39.0	Includes TNSF12, 13; CD68; TP53
chrX:150500001—151500000	DUSP9—GAB3	53	43	39.0	Includes G6PD; IRAK1
chr19:59250001—60250000	OSCAR—RDH13	49	53	36.0	Includes KIR, ILT, LILR families

Using a window offset of 250 kb, the number of genes per megabase and GC content were calculated as described in Figure 1. If a region appeared in the top 20 hits more than once (e.g., chr16:250001—250000 and chr16:5000001—1,500000), the regions were combined. “Region” indicates the outermost genes within the GoldenPath span.