Table 1.

SVM Peformance in Distinguishing Real From Pseudo Exons

Flanks		Splice sites
US	DS	3′	5′	Exon body	ROC	Specificity^a
		CV^b			0.609	0.484
+	-	-	-	-	0.791	0.638
-	+	-	-	-	0.784	0.618
+	+	-	-	-	0.855	0.695
-	-	+	-	-	0.823	0.672
-	-	-	+	-	0.837	0.698
-	-	+	+	-	0.907	0.777
+	+	+	+	-	0.932	0.825
-	-	-	-	+	0.946	0.841
+	+	-	-	+	0.984	0.956
-	-	+	+	+	0.987	0.964
+	+	+	+	+	0.991	0.976

Performances are indexed by ROC values and specificity. Each row is an SVM test. ROC values were measured in untouched sets of ∼2200 real and ∼2300 pseudo exons. The first five columns indicate the components used by SVM. US, upstream; DS, downstream; TP, true positive; FN, false negative; FP, false positive; SE, sensitivity; SP, specificity.

Specificity = TP/(TP + FP) at a sensitivity (SE = TP/(TP + FN)) of 0.90

The SVM classified on the basis of the acceptor and the donor consensus values