Table 2.
Symptomatic and biochemical response in patients treated with TAE
| Paper | Number and type of NEN | Number of TAEs | BR | SR (endocrine symptoms) | SR (aspecific symptoms) |
|---|---|---|---|---|---|
|
Loewe et al. 2003[7] |
23 small-bowel NENs |
75 |
13 pts evaluable: 8 (61%) PR, 5 (39%) MR |
9 pts evaluable: |
- - - |
| |
Abdominal pain 5 (56%) PR |
|
|||
| |
Diarrhea 2 (22%) CR |
|
|||
| |
Flushing 2 (22%) CR |
|
|||
|
Gupta et al. 2003[18] |
69 carcinoids |
Carcinoids: |
- - - |
- - - |
- - - |
| |
42 TAE/27 TACE |
|
|||
| |
54 PNENs |
PNENs: |
|
||
| |
32 TAE/22 TACE |
|
|||
|
Carrasco et al. 1986[32] |
25 carcinoids |
25 |
18 (72%) CR |
- - - |
20 (87%) CR |
|
Strosberg et al. 2006[36] |
59 carcinoids |
161 |
35 pts evaluable: |
Flushing and/or diarrhea 21 (48%) CR |
9 (20%) CR |
| |
20 PNENs |
|
28 (80%) CR |
Abdominal pain 11 (25%) CR |
(44 pts evaluable) |
| |
5 unspecified NENs |
|
4 (11%) MR |
Hypoglicemia 3 (7%) CR |
|
| |
3 (9%) no response |
(44 pts evaluable) |
|
||
|
Hanssen et al. 1989[39] |
19 carcinoids (7 pts evaluable) |
7 |
7 (100%) PR |
Diarrhea and/or flushing: 7 (100%) CR |
- - - |
|
Wangberg et al. 1996[40] |
64 carcinoids |
40 |
40 (100%) PR |
- - - |
40 (100%) PR |
| |
(40 pts evaluable) |
|
|||
|
Eriksson et al. 1998[41] |
29 carcinoids |
55 |
Carcinoids: 12 (41%) PR, 8 (28%) MR, 9 (31%) no response |
- - - |
11 carcinoid (38%) CR |
| |
12 PNENs |
|
PNEN: 6 (50%) PR, 2 (16%) MR, 4 (34%) no response |
|
6 PNEN (50%) CR |
|
Brown et al. 1999[42] |
21 carcinoids |
63 |
- - - |
- - - |
46 (96%) PR |
| |
14 PNENs |
(48 evaluable) |
|
(48 TAE evaluable) |
|
|
Chamberlain et al. 2000[43] |
41 carcinoids |
59 |
- - - |
33 pts evaluable |
31 (94%) PR |
| |
26 non functional PNENs |
|
Hormonal and/or pain symptoms |
|
|
| |
18 functional PNENs |
|
31 (94%) PR |
|
|
|
Ruutiainen et al. 2007[44] |
67 unspecified NENs |
23 TAE/44 TACE (219 procedures) |
- - - |
- - - |
- - - |
|
Ho et al. 2007[45] |
46 NENs |
7TAE/86 TACE |
- - - |
- - - |
27 pts evaluable |
| |
(31 carcinoids; 15 PNEN) |
|
21 (78%) PR |
||
|
Kamat et al. 2008[46] |
60 unspecified NENs |
33 TAE/27 TACE |
- - - |
- - - |
20 pts evaluable |
| |
(123 procedures) |
|
13 (65%) PR |
||
|
Pitt et al. 2008[47] |
100 unspecified NENs |
106TAE/123TACE |
- - - |
- - - |
35 pts evaluable: 29 TAE (83%) PR |
| |
35 pts evaluable: 32 TACE (86%) PR |
||||
|
Sward et al. 2009[48] |
107 carcinoids |
213 |
37 pts evaluable: |
Diarrhea and/or flushing 76 (71%) CR |
76 (71%) |
| |
CgA: 19 (51%) CR |
|
|||
| |
54 pts evaluable: |
|
|||
| |
5HIAA: 26 (48%) CR |
|
|||
|
Fiore et al. 22014[50] |
12 PNENs |
38 TAE/37 TACE |
- - - |
- - - |
19 pts evaluable |
| |
16 NENs ileum |
|
(64%) PR* |
||
| 2 NENs colon | |||||
Legend = PNEN: NEN pancreas, BR: biochemical response, SR: symptomatic response, PR: partial response, CR: complete response, MR: minor response.
*Cumulative results.