Table 3.

Safety of TAE

Paper	Number and type of NEN	Number of TAE	Complications	Death
Loewe et al. 2003[7]	23 small-bowel NENs	75	Decreased body weight 1 (1%)	2 (8%)
			Leg pain 1 (1%)
Gupta et al. 2003[18]	69 carcinoids	Carcinoids:	Serious adverse events 19 (15%)*	1 (1%)
	54 PNENs	42 TAE/27 TACE
		PNENs:
		32 TAE/22 TACE
Carrasco et al. 1986[32]	25 carcinoids	25	- - -	2 (8%)
	(23 evaluable)
Strosberg et al. 2006[36]	59 carcinoids	161	- - -	2 (2%)
	20 PNENs
	5 unspecified NENs
Hanssen et al. 1989[39]	19 carcinoids	7	- - -	- - -
	(7 evaluable)
Wangberg et al. 1996[40]	64 carcinoids	40	- - -	Increased risk of cardiovascular deaths (not specified)
Eriksson et al. 1998[41]	29 carcinoids	55	Unspecified severe complications 6 (10%)	13 (31%)
	12 PNENs
Brown et al. 1999[42]	21 carcinoids	63	Unspecified severe complications 11 (17%)	4 (6%)
	14 PNENs
Chamberlain et al. 2000[43]	41 carcinoids	59	- - -	4 (6%)
	26 non functional PNENs
	18 functional PNENs
Ruutiainen et al. 2007[44]	67 unspecified NENs	23 TAE/44 TACE	Unspecified toxicity 34 (50%)*	(1) 1.4%*
		(219 procedures)
Ho et al. 2007[45]	46 NENs	7 TAE/86 TACE	Unspecified complications 9 (10%)*	4 (4.3%)
	(31 carcinoids; 15 PNEN)
Kamat et al. 2008[46]	60 unspecified NENs	33 TAE/27 TACE	Unspecified complications 21 (35%)*	12 (20%)
		(123 procedures)
Pitt et al. 2008[47]	100 unspecified NENs	106TAE/123TACE	Liver abscesses, ileus, groin hematoma, hypotension 7 (13%) TAE hematoma, acute renal failure, and a biloma 3 (6%) TACE	3 (3%)*
Sward et al. 2009[48]	107 carcinoids	213	Liver abscess 4 (4%)	2 (2%)
			Mild pancreatitis 1 (1%)
			Accidental occlusions of the common hepatic artery 2 (2%)
Fiore et al. 2014[50]	12 PNENs	38 TAE/37 TACE	Post-embolization syndrome 6 (40%) TAE	0%
	16 NENs ileum		Post-embolization syndrome 8 (60%) TACE
	2 NENs colon

*Cumulative results.