Table 1.

Key angiogenic genes modulated by simvastatin in prostate cancer (PC3) cells

Gene Symbol	Gene description	Change (X-fold)
AKT1	V-akt murine thymoma viral oncogene homolog 1	4.6↓
ANGPT1	Angiopoietin 1	4.0↑
ANGPT2	Angiopoietin 2	1.8↓
CHEK2	CHK2 checkpoint homolog	1.6↓
COL18A1	Collagen, type XVIII, alpha 1	4.7↓
E2F1	E2F transcription factor 1	8.2↓
ERBB2	V-erb-b2 erythroblastic leukemia viral oncogene homolog 2	6.3↓
FGFR2	Fibroblast growth factor receptor 2	1.8↓
FOS	V-fos FBJ murine osteosarcoma viral oncogene homolog	1.6↓
IFNB1	Interferon, beta 1, fibroblast	2.4↓
IGF1	Insulin-like growth factor 1 (somatomedin C)	3.2↓
ITGA4	Integrin, alpha 4 (CD49D)	3.6↓
ITGB3	Integrin, beta 3 (glycoprotein IIIa, CD61)	2.2↓
ITGB5	Integrin, beta 5	5.5↓
JUN	Jun oncogene	5.1↓
MMP2	Matrix metallopeptidase 2	2.3↓
MTA2	Metastasis associated 1 family, member 2	3.8↓
MTSS1	Metastasis suppressor 1	2.0↓
MYC	V-myc myelocytomatosis viral oncogene homolog	3.7↓
PDGFB	Platelet-derived growth factor-β	2.0↓
PLAUR	Plasminogen activator, urokinase receptor	1.8↓
PNN	Pinin, desmosome associated protein	1.5↓
SNCG	Synuclein, gamma	3.1↓
SYK	Spleen tyrosine kinase	2.0↓
TEK	TEK tyrosine kinase, endothelial	1.9↓
VEGFA	Vascular endothelial growth factor A	4.1↓