Table 1.
Representative gene expression profile of different cell populations [23] in Matrigel plugs from Dusp3-knockout versus WT
| Gene name | Alternative names | Ratio Dusp3 -KO/WT | P value |
|---|---|---|---|
|
Endothelial cells
| |||
|
Pecam1 |
Cd31; PECAM-1 |
0.52 |
0.045* |
|
Mcam |
CD146; CD149 |
0.46 |
0.060 |
|
Tie1 |
TIE; tie-1 |
0.37 |
0.059 |
|
Cdh5 |
VECD; Cd144; VE-Cad; |
0.35 |
0.038* |
|
Pericytes
| |||
|
Cspg4 |
AN2; NG2 |
0.76 |
0.25 |
|
Pdgfrb |
CD140b; PDGFR-1 |
0.66 |
0.047* |
|
Acta2 |
a-SMA; alphaSMA |
0.29 |
0.034* |
|
Lymphoid and Myeloid markers
| |||
|
Csf1r |
CD115; CSF-1R |
1.2 |
0.58 |
|
Itgam |
MAC1; Cd11b; CD11b/CD18 |
1.1 |
0.31 |
|
Klrb1c |
CD161; NK1.1 |
1.1 |
0.85 |
|
Ly6a/e |
Sca1; Ly-6A.2 |
1.1 |
0.56 |
|
Ly6c1 |
Ly6c |
1.1 |
0.56 |
|
Emr1 |
F4/80 |
1.0 |
0.95 |
|
Lgals3 |
Mac-2 |
1.0 |
0.58 |
| Csf1r | CD115; CSF-1R | 1.0 | 0.97 |
Data presented are extracted from a genome-wide microarray dataset obtained using Illumina’s multi sample format Mouse WG-6 V2 BeadChip. Data are presented as the ratio of the average values obtained from 2 pools of 3 Dusp3-knockout each on 2 pools of 3 WT mice each and the corresponding p-value. (*p < 0.05 determined using unpaired student’s t test).