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. Author manuscript; available in PMC: 2015 Jun 6.
Published in final edited form as: Neuroscience. 2014 Mar 21;269:35–42. doi: 10.1016/j.neuroscience.2014.03.023

Figure 1. Impaired active avoidance learning in IA-2, but not IA-2β, SKO mice.

Figure 1

(A) Mean percentage of trials on which active avoidance responses was made during each session of 50 trials (2 sessions per day) over 5 days. Both the DKO and IA-2 SKO mice failed to show active avoidance learning in contrast to the WT and IA-2β SKO mice. (B) Duration of active avoidance learning after 5 days of training. Mice then were retested on days 20 and 50. Both WT and IA-2β SKO mice continued to show strong active avoidance. Each group initially consisted of 6 mice. At the start of the experiment mice were 10 ± 2 weeks of age. We were unable to determine if active avoidance responses were maintained across genotypes at day 50 due to the death of several animals resulting in loss of statistical power. Vertical lines represent mean ± SEM. (**) P<0.01, (***) P<0.001.