Table 4.
Sensitivity analysis on pregnancy, fetal, and neonatal outcomes: propensity score matched analysis
| No (%) of cases | Adjusted odds ratio (95% CI) | ||
|---|---|---|---|
| Unvaccinated (n=22 145) | Vaccinated (n=5776) | ||
| Pregnancy outcomes | |||
| Pre-eclampsia/eclampsia | 675 (3.0) | 210 (3.6) | 1.19 (1.01 to 1.39) |
| Gestational diabetes | 422 (1.9) | 139 (2.4) | 1.25 (1.03 to 1.52) |
| In-hospital maternal death | 0 | 0 | — |
| Admission to ICU | 39 (0.2) | 10 (0.2) | 1.04 (0.52 to 2.09) |
| Type of delivery: spontaneous v others | 14 841 (67.0) | 3875 (67.1) | 1.00 (0.94 to 1.07) |
| Fetal and perinatal outcomes | |||
| Stillbirths | 49 (0.2) | 14 (0.2) | 1.10 (0.60 to 2.01) |
| In-hospital neonatal death | 16 (0.1) | 4 (0.1) | 0.98 (0.33 to 2.95) |
| Perinatal death | 65 (0.3) | 18 (0.3) | 1.07 (0.63 to 1.82) |
| Neonatal outcomes | |||
| Small for gestational age | 2134 (9.6) | 523 (9.1) | 0.93 (0.84 to 1.03) |
| Admission to neonatal ICU | 416 (1.9) | 128 (2.2) | 1.16 (0.95 to 1.42) |
| Neonatal reanimation | 174 (0.8) | 56 (1.0) | 1.24 (0.92 to 1.68) |
| Composite outcome | 646 (2.9) | 158 (2.7) | 0.92 (0.77 to 1.02) |
| Congenital malformations:* | 873 (3.9) | 260 (4.5) | 1.14 (0.99 to 1.31) |
| Nervous system | 40 (0.2) | 12 (0.2) | 1.15 (0.60 to 2.19) |
| Eye | 8 (0.04) | 3 (0.1) | 1.46 (0.39 to 5.50) |
| Ear, face, and neck | 26 (0.1) | 10 (0.2) | 1.36 (0.65 to 2.84) |
| Congenital heart defects | 319 (1.4) | 105 (1.8) | 1.25 (1.00 to 1.57) |
| Respiratory | 13 (0.1) | 6 (0.1) | 2.00 (0.79 to 5.01) |
| Orofacial clefts | 17 (0.1) | 3 (0.1) | 0.64 (0.18 to 2.22) |
| Digestive system | 69 (0.3) | 22 (0.4) | 1.17 (0.72 to 1.89) |
| Abdominal wall defects | 2 (0.00) | 2 (0.03) | 4.00 (0.61 to 28.39) |
| Urinary | 121 (0.5) | 28 (0.5) | 0.92 (0.61 to 1.39) |
| Genital | 6 (0.03) | 0 | — |
| Limb | 266 (1.2) | 75 (1.3) | 1.06 (0.82 to 1.38) |
| Other anomalies | 23 (0.1) | 6 (0.1) | 1.03 (0.42 to 2.54) |
ICU=intensive care unit.
*At least one.