Table 1.
Demographic and Clinical Characteristics at Index PFT
| All C-TIS Patients |
All Comparator Intervals |
Target C-TIS Patients |
Target Comparator Intervals |
||
|---|---|---|---|---|---|
| N | 2,534 | 17,656 | 1,448 | 6,019 | |
| Age, mean (SD) | 17.5 (7.3) | 16.2 (7.2) | 19.0 (7.3) | 19.7 (7.7) | |
| Age group (yr), % | |||||
| 8–12 | 29.0 | 41.4 | 20.5 | 20.9 | |
| 13–17 | 29.8 | 23.4 | 28.3 | 21.8 | |
| 18–38 | 41.2 | 35.2 | 51.2 | 57.3 | |
| Female, % | 50.2 | 47.7 | 51.7 | 51.2 | |
| delta F508 homozygous*, % (n) | 57.5 (n = 1,713) | 53.3 (n = 11,514) | 55.7 (n = 912) | 54.6 (n = 3,519) | |
| Pseudomonas* positive, % (n) | 76.5 (n = 957) | 56.2 (n = 7,775) | 85.8 (n = 514) | 84.5 (n = 2,566) | |
| FEV1 (% pred), mean (SD) | 62.6 (24.2) | 74.7 (26.1) | 50.9 (13.9) | 51.8 (14.1) | |
| FEV1 groups, % | |||||
| <25% pred. | 4.5 | 3.0 | — | — | |
| 25–<50% pred. | 29.7 | 17.7 | 48.1 | 44.8 | |
| 50–<75% pred. | 33.2 | 25.2 | 51.9 | 55.2 | |
| ≥75% pred. | 32.5 | 54.1 | — | — | |
| Weight for age*, mean (SD) | 27.2 (25.1) | 32.4 (27.5) | 22.8 (23.0) | 24.7 (24.8) | |
| Pulmonary signs and symptoms* positive, % | |||||
| Sputum production | 84.1 | 71.1 | 90.3 | 89.2 | |
| Cough | 95.4 | 89.2 | 97.2 | 97.3 | |
| Crackles | 37.8 | 24.4 | 46.8 | 44.6 | |
| Wheeze | 8.5 | 7.1 | 9.4 | 9.8 | |
| Digital clubbing | 68.5 | 59.8 | 77.5 | 76.1 | |
*
Includes only patients with nonmissing data at index PFT. Approximately 1,500 and 800 intervals are missing weight for age and pulmonary signs and symptoms data from all and target populations, respectively. (n) indicates the denominator for that particular percentage.