Figure 1.

Proposed strategy to break the enzootic cycle of the Lyme disease spirochete. A, The triad which comprises the enzootic cycle: the tick vector (Ixodes scapularis), the major reservoir host (white footed-mouse), and Borrelia burgdorferi. B, Hypothesis: immunizing wild white-footed mice with oral reservoir-targeted vaccine (RTV) breaks the enzootic cycle of B. burgdorferi. C, Field study design and methods. Abbreviations: Ab, antibody; Ctrl, control plot; FlaB, Flagellin B; OspA, outer surface protein A; PCR, polymerase chain reaction.