Figure 2.

Mean lung fungal burden in mice treated for either 7 days or 21 days with 80 mg/kg nikkomycin Z (NikZ) once daily and euthanized 48 hours or 3 weeks after discontinuing drug therapy. All NikZ treatments yielded significantly better results than placebo (P < .001). NikZ administered for 7 days to mice that were euthanized 2 days after cessation of treatment yielded significantly worse results than when administered for 21 days to mice euthanized 2 days after treatment cessation (P = .0276), but results did not differ between the 21-day treatment groups euthanized 2 and 21 days after treatment cessation. Numbers in parentheses are culture-negative animals. The asterisk denotes a culture-negative mouse in the placebo group that was probably uninfected because of technical reasons. Statistical comparisons were performed by analysis of variance.