Table 2.
Therapeutic Efficacy of Sm-p80 Using Recombinant Protein and Prime Boost Approaches for Schistosoma mansoni in Baboons
| Group, Baboon | Individual-Level Findings, Mean ± SE |
Group-Level Findings, Mean ± SE |
Percentage Reduction From Controla |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex | Age, y | Worm Burden, No. | Tissue Egg Burden, Eggs/g | Fecal Egg Burden, Eggs/g | Worm Burden, Worms, No. | Tissue Egg Burden, Eggs/g | Fecal Egg Burden, Eggs/g | Worm Burden | Tissue Egg Burden | Fecal Egg Burden | |
| GLA-SE control | 556.50 ± 72.06 | 6345.01 ± 679.40 | 101.11 ± 5.62 | … | … | … | |||||
| IS84 | F | 13.41 | 415 | 5363.42 ± 1714.28 | 133.75 ± 12.47 | ||||||
| IN61 | F | 4.64 | 727 | 6163.22 ± 1657.71 | 92.21 ± 10.22 | ||||||
| BA02 | M | 9.59 | 462 | 8316.97 ± 3677.79 | 54.95 ± 6.46 | ||||||
| ST32 | M | 8.70 | 622 | 5536.44 ± 2376.92 | 123.51 ± 10.57 | ||||||
| rSm-p80 + GLA-SE | 356.00 ± 39.23 | 2930.70 ± 241.43 | 67.72 ± 3.57 | 36.06 | 53.81 | 33.02 | |||||
| ZO00 | F | 10.99 | 262 | 3054.32 ± 326.94 | 63.42 ± 6.00 | ||||||
| PO96 | M | 9.79 | 336 | 2341.31 ± 837.72 | 59.77 ± 7.01 | ||||||
| ED59 | M | 8.90 | 376 | 3501.46 ± 1187.86 | 69.25 ± 8.16 | ||||||
| AN63 | F | 13.30 | 450 | 2825.72 ± 407.90 | 78.46 ± 7.14 | ||||||
| VR1020 + alum control | 881.00 ± 2.00 | 2509.17 ± 585.83 | 27.32 ± 9.11 | … | … | … | |||||
| ES45 | F | 5.60 | 883 | 3095.00 ± 1665.00 | 23.15 ± 9.40 | ||||||
| KI11 | M | 4.50 | 879 | 1923.33 ± 743.33 | 31.48 ± 17.59 | ||||||
| Sm-p80–VR1020 + rSm-p80 + alum | 792.50 ± 56.50 | 2254.04 ± 848.63 | 23.15 ± 7.94 | 10.05 | 10.17 | 15.25 | |||||
| TO81 | M | 4.34 | 736 | 3102.67 ± 989.33 | 10.19 ± 6.07 | ||||||
| FO45 | M | 4.48 | 849 | 1405.42 ± 972.08 | 36.11 ± 10.52 | ||||||
| VR1020 + CpG- ODN control | 729.00 ± 64.00 | 3440.00 ± 1462.31 | 28.24 ± 7.43 | … | … | … | |||||
| RA75 | M | 4.00 | 665 | 3893.33 ± 2811.22 | 27.78 ± 9.75 | ||||||
| CY62 | F | 4.60 | 793 | 2986.67 ± 1193.17 | 28.70 ± 13.45 | ||||||
| Sm-p80–VR1020 + rSm-p80 + CpG-ODN10104 | 560.00 ± 108.00 | 1465.00 ± 345.70 | 24.54 ± 3.61 | 23.18 | 57.41 | 13.11 | |||||
| ZU03 | F | 5.90 | 452 | 1013.33 ± 421.48 | 24.07 ± 8.07 | ||||||
| LU04 | M | 5.40 | 668 | 1916.67 ± 516.33 | 25.00 ± 0.00 | ||||||
Abbreviations: GLA, glucopyranosyl lipid adjuvant; SE, standard error.
a P ≤ .05 for worm burden, ≤.01 for tissue egg burden, and <.0001 for fecal egg burden.