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Schematic of complement C3 activation and degradation. After activation by the convertase, C3 is subject to normal degradation involving sequential factor I cleavage with factor H cofactor activity. iC3b is then subject to PSA cleavage after tyrosine-1348 and potentially other uncharacterized sites. PSA cleavage results in the production of a new 37-kDa fragment. The black square indicates the thioester site within C3.
