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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Chem Commun (Camb). 2014 May 18;50(38):4904–4907. doi: 10.1039/c4cc00967c

Table 1.

Biological data of activities of known compounds and synthesized molecules.

Compound Structure rat
FAAH
IC50
(nM)
human
FAAH
IC50
(nM)
DRD3
EC50
(nM)
DRD3%
Efficacy*
DRD2
EC50
(nM)
DRD2%
Efficacy**
Ratio
D2/D3
CB1
EC50
(nM)
Ratio
CB1/D3
7 graphic file with name nihms-588791-t0003.jpg 0.3 1.6 6.5 51.7 >1000 41.2 >154 0.9 0.1
8 graphic file with name nihms-588791-t0004.jpg 0.1 1.3 3.9 64.8 320.0 61.1 82 0.3 0.1
15 graphic file with name nihms-588791-t0005.jpg 0.7 0.6 1.0 55.6 23.0 25.2 23 14.0 14
16 graphic file with name nihms-588791-t0006.jpg 13.0 2.7 7.7 81.2 240.0 32.3 31 64.0 8
17 graphic file with name nihms-588791-t0007.jpg 22.0 6.1 1.3 50.4 209.0 A 161 420.0 323
*

vs. 300 nM dopamine;

**

vs. 3 μM dopamine;

N.C., value not calculable, concentration – response curve show less than 25% effect at the highest concentration; A, antagonist