Table 1.

Biological data of activities of known compounds and synthesized molecules.

Compound	Structure	rat FAAH IC50 (nM)	human FAAH IC50 (nM)	DRD3 EC50 (nM)	DRD3% Efficacy*	DRD2 EC50 (nM)	DRD2% Efficacy**	Ratio D2/D3	CB1 EC50 (nM)	Ratio CB1/D3
7		0.3	1.6	6.5	51.7	>1000	41.2	>154	0.9	0.1
8		0.1	1.3	3.9	64.8	320.0	61.1	82	0.3	0.1
15		0.7	0.6	1.0	55.6	23.0	25.2	23	14.0	14
16		13.0	2.7	7.7	81.2	240.0	32.3	31	64.0	8
17		22.0	6.1	1.3	50.4	209.0	A	161	420.0	323

^*vs. 300 nM dopamine;

^**vs. 3 μM dopamine;

N.C., value not calculable, concentration – response curve show less than 25% effect at the highest concentration; A, antagonist