Table 2.

Mortality Risk of Inflammatory Phenotype in 1-, 2-, and 10-Year Cardiovascular Health Study (CHS) Cohort

	10-Year CHS			1-Year CHS			2-Year CHS
Variables	HR	95% CI		HR	95% CI		HR	95% CI
Log(IL-6)	1.42	1.36	1.49	1.87	1.56	2.24	1.72	1.52	1.95
Log(sTNFR1)	1.46	1.39	1.53	1.98	1.69	2.32	1.72	1.52	1.94
Log(CRP)	1.25	1.19	1.31	1.63	1.33	1.98	1.59	1.39	1.82
Log(IL-18)	1.10	1.05	1.15	1.26	1.02	1.56	1.25	1.08	1.44
Log(IL-1RA)	1.21	1.15	1.26	1.44	1.19	1.73	1.29	1.13	1.48
Age	1.80	1.72	1.87	1.53	1.27	1.83	1.62	1.43	1.83
WSS	1.47	1.41	1.54	2.14	1.77	2.58	1.88	1.65	2.15
PCS	1.44	1.37	1.50	2.04	1.69	2.47	1.85	1.62	2.11
IIS	1.62	1.54	1.70	2.45	2.02	2.96	2.06	1.80	2.36
IIS*	1.88	1.77	2.00	3.21	2.50	4.11	2.58	2.16	3.08

Notes: CRP = C-reactive protein; HR = hazard ratio; IIS = inflammation index score; IIS* = stratified inflammatory index; IL-6 = interleukin-6; IL-18 = interleukin-18; IL-1RA = IL-1-receptor antagonist; PCS = principal components summary score; sTNFR1 = soluble tumor necrosis factor-α receptor-1; WSS = weighted summary score.

HR is the change in hazard of mortality per 1 standard deviation (SD) increase in the value of variables.

All analyses were adjusted for age, CVD, gender, education, smoke, and body mass index (BMI; except for age-only model), and the IIS* model was only adjusted for age, education, smoking, and BMI.

IIS and IIS* was calculated as follows:

IIS = 1/3 log(IL-6) + 2/3 log(sTNFR1), for all individuals.

IIS* = 1/3 log(IL-6) + 2/3 log(sTNFR1), if female and non-CVD.

   2/5 log(IL-6) + 3/5 log(sTNFR1), if male and non-CVD,

   1/4 log(IL-6) + 3/4 log(sTNFR1), if female and CVD,

   1/3 log(IL-6) + 2/3 log(sTNFR1), if male and CVD.