Table 2.
Association of Change in Biomarker Level With Change in Cognitive Function, With Each Biomarker Entered Separately
| Δ 3MSE | N = 793 | Δ DSST | N = 771 | ||
|---|---|---|---|---|---|
| Δ Biomarker | SD Units | β (95% CI) | p | β (95% CI) | p |
| DHEAS | −0.29 µg/mL | 0.567 (−0.144, 1.277) | .119 | W: 1.455 (0.475, 2.436) | .004 |
| M: −0.717 (−1.911, 0.478) | .240 | ||||
| Adiponectin | 5.08ng/mL | W: −0.819 (−1.708, 0.069) | .071 | 0.360 (−0.414, 1.134) | .363 |
| M: 0.641 (−0.450, 1.732) | .250 | ||||
| IGF-1 | −46.8ng/mL | 0.305 (−0.373, 0.982) | .378 | 0.098 (−0.635, 0.831) | .794 |
| IGFBP-1 | 32.7ng/mL | −0.252 (−0.953, 0.448) | .481 | −0.008 (−0.781, 0.765) | .984 |
| IGFBP-3 | −609mg/L | −0.331 (−1.005, 0.343) | .335 | 0.344 (−0.388, 1.076) | .357 |
| IL-6 | 2.50 pg/mL | −0.491 (−1.170, 0.189) | .157 | −0.834 (−1.571, −0.097) | .027 |
| Cholesterol | −40mg/dL | −0.172 (−0.850, 0.506) | .620 | 0.669 (−0.064, 1.401) | .074 |
Note: Models are adjusted for age, sex, black race (Y or N), current smoking status (Y or N), current marital status (Y or N), number of chronic diseases, change in weight during follow up, mean of 1996–1997 and 2005–2006 biomarker level in standard deviation (SD) units, and interaction of biomarker change with sex, if significant. When the sex interaction is significant, results for women (W) and men (M) are given separately. Bold p values indicate p < .05. CI = confidence interval; DHEAS = dehydroepiandrosterone sulfate; DSST = Digit Symbol Substitution Test; IGF-1 = insulin-like growth factor 1; IGFBP-1 and 3 = IGF binding proteins 1 and 3; IL-6 = interleukin-6; MSE = Modified Mini Mental Status Exam; SD = standard deviation.