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. Author manuscript; available in PMC: 2014 May 29.
Published in final edited form as: Science. 2011 Dec 23;334(6063):1669–1675. doi: 10.1126/science.1208049

Fig. 6. Acute expression of Npas4 in CA3 reverses short-term and long-term memory deficits observed in Npas4-/- mice.

Fig. 6

(A) Expression of Npas4 in CA3 of Npas4-/- mice using HSV-Npas4.

(B) Npas4, but not ΔNpas4, restores expression of c-Fos in vivo.

(C) Expression of Npas4, but not ΔNpas4, drives activity of PIBDNF independent of KCl depolarization. n = 4 cultures. *p ≤ 0.001.

(D) Npas4-/- mice with Npas4 injected into CA3 freeze at similar levels to Npas4+/+ mice injected with GFP 1hr and 24hrs after training. CA1 injection of Npas4 or CA3 injection of ΔNpas4 did not reverse the memory deficit. *p < 0.001.