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. Author manuscript; available in PMC: 2014 May 29.
Published in final edited form as: Dev Biol. 2012 Apr 28;367(1):25–39. doi: 10.1016/j.ydbio.2012.04.018

Fig. 3.

Fig. 3

Conditional mutations of En1/2 in the VZ and RL at e10.5 with NP-Cre reveals a requirement for En1/2 in the granule cell lineage for growth of the vermus and foliation defects. Sagittal H&E-stained sections of P0 (A–H) and adult (I–P) mutants with the genotypes indicated showing the vermis (A, C, E, G, I, K, M & O) and hemispheres (B, D, F, H, J, L, N & P). a, ansoparamedian; pc, preculminate; po, posterolateral; prc, precentral; ppy, prepyramidal; pr, primary; sec, secondary; black arrowheads, vermal anterior fissures; white arrowheads, vermal posterior fissures; white arrow, hemisphere fissure. Stars denote fissures with developmental defects and yellow highlighted areas denote regions with defects in mutants compared to same region in the control. Genotypes colored blue represent conditional mutants with one functional allele of En1 and genotypes colored red represent conditional mutants with one functional allele of En2. Scale bar: 400μm for A–H; 600μm for I–P.