Figure 7. Luciferase gene expression following US/MB-mediated gene delivery into rat liver.

A solution of pGL4 plasmid, MBs, and glucose was injected slowly (45 seconds) into a portal vein branch using a 24-ga catheter, with simultaneous exposure to US (1.1 MHz, 20 cycle pulses, 13.9 Hz PRF, and 2.7 MPa PNP) for 90 seconds. Blood samples and treated lobes were harvested after 24 hours. Average luciferase expression for each group is shown, and error bars indicate STD (n=4–6). * p<0.05.