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. 2014 Mar 18;41(3):227–237. doi: 10.1111/1440-1681.12204

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© 2014 The Authors. Clinical and Experimental Pharmacology and Physiology Published by Wiley Publishing Asia Pty Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Fig. 5 — (a) Proteinuria and (b) creatinine clearance in sham-operated Hannover Sprague-Dawley rats (HanSD; transgene negative; ) and heterozygous Ren-2 transgenic rats (TGR; ▪), as well as in TGR rats after 5/6 renal mass reduction (5/6 NX) that were either untreated () or treated with: (i) combined renin–angiotensin system (RAS) blockade with trandolapril, an angiotensin-converting enzyme inhibitor, and losartan, an angiotensin receptor blocker (); or (ii) the soluble epoxide hydrolase inhibitor cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid (). Data are the mean ± SEM. *P < 0.05 compared with sham-operated HanSD rats at the same time point; ^†P < 0.05 compared with sham-operated TGR at the same time point. (), HanSD; (), 5/6 NX TGR + water; (), 5/6 NX TGR + sEHi; (▪), TGR; (), 5/6 NX TGR + RAS blockade.

Inline graphic — (a) Proteinuria and (b) creatinine clearance in sham-operated Hannover Sprague-Dawley rats (HanSD; transgene negative; ) and heterozygous Ren-2 transgenic rats (TGR; ▪), as well as in TGR rats after 5/6 renal mass reduction (5/6 NX) that were either untreated () or treated with: (i) combined renin–angiotensin system (RAS) blockade with trandolapril, an angiotensin-converting enzyme inhibitor, and losartan, an angiotensin receptor blocker (); or (ii) the soluble epoxide hydrolase inhibitor cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid (). Data are the mean ± SEM. *P < 0.05 compared with sham-operated HanSD rats at the same time point; ^†P < 0.05 compared with sham-operated TGR at the same time point. (), HanSD; (), 5/6 NX TGR + water; (), 5/6 NX TGR + sEHi; (▪), TGR; (), 5/6 NX TGR + RAS blockade.