Table 3.
Week of treatment | Weight loss not on target, N (%) | Weekly attendance, N (%) | Drop-out, N (%) | Clinically significant weight loss at 6 months, by early-treatment weight loss | |||||
---|---|---|---|---|---|---|---|---|---|
Se, % | Sp, % | 5% or greater weight loss at 6 months among those whose early- treatment weight loss was on target N (%) | 5% or greater weight loss at 6 months among those whose early-treatment weight loss was not on target N (%) | Crude RR (95% CI) | Adjusted RR (95% CI) | ||||
Week 4 | 7 (16) | 38 (88) | -- | 25 | 91 | 21 (58) | 2 (29) | 2.04 (0.61–6.80) | 4.23 (0.65–27.45)a |
Week 5 | 9 (21) | 36 (84) | -- | 35 | 91 | 21 (62) | 2 (22) | 2.78 (0.80–9.71) | 4.71 (0.72–30.92)b |
Week 6 | 15 (35) | 33 (77) | -- | 55 | 83 | 19 (68) | 4 (27) | 2.54 (1.06–6.12) | 2.88 (1.02–8.12) a |
Week 7 | 15 (35) | 31 (72) | -- | 55 | 83 | 19 (68) | 4 (27) | 2.52 (1.06–6.12) | 3.34 (1.21–9.20) a |
Week 8 | 18 (42) | 33 (77) | 1 (2) | 70 | 83 | 19 (76) | 4 (22) | 3.42 (1.40–8.34) | 4.03 (1.41–11.52) a |
Se: sensitvity, i.e., proportion of women failing to achieve 5% or greater weight loss at 6 months who were not on target with their weight loss at a given week early in treatment; Sp: specificity, i.e., proportion of women achieving 5% or greater weight loss at 6 months who were on target with their weight loss at a given week early in treatment.
Adjusted for smoking (never versus former smoking);
Adjusted for smoking (never versus former smoking) and depressive symptoms (BDI; continuous) at study baseline.