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The predicted binding conformation of compound 13 (blue) in the active site of AKR1C3. Relevant enzyme residues are shown as green sticks, the catalytic tetrad is presented as yellow sticks, the co-crystallized indomethacin as magenta sticks and the cofactor as orange sticks. Compound 13 occupies a portion of the SP3 pocket which up until now has only been occupied by indomethacin.
