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. 2014 May 29;10(5):e1003578. doi: 10.1371/journal.pcbi.1003578

Table 1. Advantage of the pooling approach.

Query Gene Set Inline graphic Inline graphic
Blood Vessel Development Gene Set 0.0698 0.2428
Bone Development Gene Set 0.1930 0.4574
Brain Development Gene Set 0.1252 0.2887
Heart Development Gene Set 0.0990 0.2781
Kidney Development Gene Set 0.1532 0.3507
Liver Development Gene Set 0.2350 0.5632
Lung Development Gene Set 0.1438 0.3460
Nerve Development Gene Set 0.3296 0.6140
Skin Development Gene Set 0.3007 0.5176

Average probabilities (over 100 trials) that random, withheld gene-disease links support nodes more significant by the traditional method (Inline graphic) or the proposed pooling method (Inline graphic) for the 9 query gene sets. Significance in each trial was computed without the withheld links. When Inline graphic is larger than Inline graphic, the nodes that are more significant under the pooling approach tend to be more consistently supported by the withheld data, our proxy for correctness.