Table 3. Logistic regression analysis comparing POAG patients with controls.
| Whole group | HTG | NTG | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Predictor variables | Odds ratio (95% CI) | P value | Odds ratio (95% CI) | P value | Odds ratio (95% CI) | P value |
| MtDNA haplogroup a | ||||||
| H | 0.62 (0.26-1.50) | 0.292 | 0.97 (0.43-2.18) | 0.934 | 0.51 (0.20-1.28) | 0.151 |
| T | 0.42 (0.12-1.48) | 0.176 | 0.65 (0.21-2.00) | 0.457 | 0.37 (0.10-1.45) | 0.154 |
| J | 3.79 (0.86-16.63) | 0.077 | 1.64 (0.34-8.05) | 0.540 | 4.42 (1.04-18.92) | 0.045 |
| U | 1.68 (0.50-5.62) | 0.401 | 2.02 (0.62-6.62) | 0.246 | 1.85 (0.53-6.38) | 0.332 |
| Others | 0.82 (0.24-2.82) | 0.757 | 0.65 (0.19-2.21) | 0.490 | 0.72 (0.21-2.52) | 0.609 |
|
| ||||||
| Compound genotype b | ||||||
| CT/TT | 56.52 (5.98-533.78) | < 0.001* | 9.91 (1.74-56.57) | 0.010 | 29.75 (3.83-231.21) | < 0.001* |
Our logistic regression models also incorporated the following predictor variables with the controls acting as the reference group: (i) age, (ii) gender, and (iii) maximum IOP, except in the HTG subgroup where maximum IOP was not included;
Significant with Bonferroni correction:
P < 0.01
P < 0.008.