. Author manuscript; available in PMC: 2014 May 29.

Published in final edited form as: J Med Genet. 2009 Jul 5;47(2):120–125. doi: 10.1136/jmg.2009.067512

Table 5. Summary of previous studies investigating the role of OPA1 polymorphisms in POAG.

Study^a	Population	Significant association				High-risk compound genotype (NTG)
		HTG	N =	NTG	N =	IVS8+4/+32	Odds ratio^b	95% CI
[11,12]	Caucasian	No	90	Yes	163	CT/TC	6.25	2.67-14.59
[13]	Caucasian	N/A	-	Yes	61	CC/CC	2.71	1.31-5.57
[14]	Japanese	N/A	-	No	337	-	-	-
[15]	Korean	N/A	-	No	65	-	-	-
[24]	Indian	N/A	-	No	50	-	-	-
[24]	Chinese	N/A	-	No	53	-	-	-
[24]	Japanese	N/A	-	No	42	-	-	-
[25]	African-Caribbean	No	48	No	61	-	-	-
[23]	Japanese	No	191	Yes	194	CC/TC	2.14	1.32-3.45
[26]	Caucasian	No	279	N/A	-	-	-	-
[26]	African-American	No	193	N/A	-	-	-	-
[26]	African	No	170	N/A	-	-	-	-

N/A: Not assessed; N: Number of patients analysed;

Studies in chronological order

Odds ratio were derived by χ² analysis using published figures and additional unpublished data provided by Dr Vincent Raymond (Personal communication) for study [14].