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. 2014 Jun 1;25(11):1769–1781. doi: 10.1091/mbc.E13-05-0292

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© 2014 Giurisato et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — KSR2 is required for CN activation. (A) Confocal microscopy of NFAT nuclear translocation in wt (top) and ksr2^−/− (bottom) fibroblasts expressing GFP-NFAT (green) and stimulated without (basal) or with 1 μM Tg for 30 min followed by TO-PRO-3 staining of the nucleus (purple). The merge of NFAT and TO-PRO-3 staining (right) shows the NFAT translocation into the nucleus in wt cells. Representative cells for each condition of three experiments is shown. Quantitative analysis (mean ± SD) of wt and ksr2^−/− cells with nuclear GFP-NFAT before and after stimulation with Tg from three experiments is shown in the graph bars. *p < 0.01. Bar, 5 μm.