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. 2014 May 29;9(5):e98293. doi: 10.1371/journal.pone.0098293

Figure 2. Identification of 73 genes amplified in TCGA datasets.

Figure 2

From the initial list of 461 genes amplified in one or more TCGA datasets, 73 amplified genes were identified with potentially “druggable” properties as well as established/putative roles in oncogenesis. Genes/amplicons are arranged by chromosomal location, with their genomic location marked as shown (Mb = Megabase). Colored boxes indicate cancer types with TCGA designations, as follows: BLCA - Bladder Urothelial Carcinoma, BRCA - Breast invasive carcinoma, CRC – Colorectal Cancer (COAD and READ studies combined together), GBM - Glioblastoma multiforme, HNSC - Head and Neck squamous cell carcinoma, KIRC - Kidney renal clear cell carcinoma, LGG - Brain Lower Grade Glioma, LUAD - Lung adenocarcinoma, LUSC - Lung squamous cell carcinoma, OV - Ovarian serous cystadenocarcinoma, PRAD - Prostate adenocarcinoma, SKCM - Skin Cutaneous Melanoma, STAD - Stomach adenocarcinoma, UCEC - Uterine Corpus Endometrioid Carcinoma.