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. 2014 May 29;9(5):e97954. doi: 10.1371/journal.pone.0097954

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© 2014 Lee et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(b), (j) Automated gland segmentation of gland boundaries. (c), (k) Subgraphs showing connections between neighboring glands. An enlarged view of the boxed region in (a) and (i) respectively, illustrates (e), (m) segmented glands, (f), (n) gland angles, and (g), (o) gland network subgraphs. (f), (n) Arrows denote the directionality of each gland. Boundary colors (blue to red) correspond to angles 180°]. (g), (o) Localized gland networks define the region of each angular co-occurrence matrix. (d), (l) Summed angular co-occurrence matrices denote the frequency with which two glands of two directionalities co-occur across all neighborhoods (white elements reflect greater co-occurrence). Diagonal co-occurrence values have been omitted to provide better contrast compared to the off-diagonal components. (h), (p) Colormap of the gland subgraphs correspond to the intensity average in each neighborhood.

Inline graphic — (b), (j) Automated gland segmentation of gland boundaries. (c), (k) Subgraphs showing connections between neighboring glands. An enlarged view of the boxed region in (a) and (i) respectively, illustrates (e), (m) segmented glands, (f), (n) gland angles, and (g), (o) gland network subgraphs. (f), (n) Arrows denote the directionality of each gland. Boundary colors (blue to red) correspond to angles 180°]. (g), (o) Localized gland networks define the region of each angular co-occurrence matrix. (d), (l) Summed angular co-occurrence matrices denote the frequency with which two glands of two directionalities co-occur across all neighborhoods (white elements reflect greater co-occurrence). Diagonal co-occurrence values have been omitted to provide better contrast compared to the off-diagonal components. (h), (p) Colormap of the gland subgraphs correspond to the intensity average in each neighborhood.