Figure 2. Histological evaluation shows that Ncf1* mice develop a severe chronic colitis with several inflammatory foci and dysplasia, particularly in the proximal and transversal sections of the colon, with a skewed leukocyte distribution.

A) Inflammatory score in the different sections of the colon throughout the experimental period. B) Dysplasia score in the different sections of the colon throughout the experimental period. C) Distribution of the leukocytes subsets in the different sections of the colon throughout the experimental period. Asterisks indicate p<0.05, Mann-Whitney test between Ncf1* and WT. Inflammation and dysplasia scoring system is detailed in the methods section.