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. 2014 May 1;124(6):2736–2749. doi: 10.1172/JCI73072

Figure 2. Bicc1 perturbation alters BMD in vivo.

Figure 2

Femoral BMD at 12, 16, and 28 weeks of age in male (A) and female (B) Bicc1+/jcpk (red) and Bicc1+/+ littermate controls (black). Change in BMD between 12 and 28 weeks of age in male Bicc1+/jcpk and Bicc1+/+ littermate controls (C). Cortical bone parameters at the femoral diaphysis determined by micro-CT in 28-week-old male Bicc1+/jcpk mice and their Bicc1+/+ littermate controls (D–I). Trabecular bone parameters at the distal femur determined by micro-CT in 28-week-old male Bicc1+/jcpk mice and their Bicc1+/+ littermate controls (J–M). Tb N, trabecular number; Tb Sp, trabecular separation. Data presented in all panels are the means ± SEM. #P < 0.10; *P < 0.05 ; **P < 0.01.