Figure 7. Variants in human BICC1 and PKD2 are association with BMD.

Plotted are the –log₁₀ (P values) for associations between SNPs in the vicinity of BICC1 and BMD in GEFOSII (red squares), MESA (black circles; left axis) and BICC1 expression in skeletal muscle (blue triangles; right axis) (A). Associations between PKD2 SNPs and BMD in GEFOSII (red squares) (B). Black dotted horizontal lines in both panels are the thresholds for statistical significance of the BMD associations. The locations of SNPs are plotted across the x axis (A and B). Location of BICC1 and PKD2 is provided in the bottom of each panel. Narrow lines represent introns, and thick lines are the locations of exons (A and B). Both genes are transcribed on the forward strand (A and B).