Skip to main content
. 2014 May 1;124(6):2651–2667. doi: 10.1172/JCI73579

Figure 6. PTEN/AKT signaling is dysregulated in miR-486–overexpressing mouse muscle.

Figure 6

(A) Western blot images of whole-tissue lysates from adult WT and Tg(Cmk-Mir486) mouse TA muscles. Three mice were used per genotype cohort. (B) Western blot densitometry values of phospho-AKT (S473), phospho-AKT (T308), AKT1/2/3, and PTEN protein images normalized to both the first lane and the β-actin–loading control. (C) Western blot images of whole-tissue lysates from adult Dmdmdx-5Cv and Dmdmdx-5Cv Tg(Cmk-Mir486). Three mice were used per genotype cohort. (D) Western blot densitometry values of phospho-AKT (S473), phospho-AKT (T308), AKT1/2/3, and PTEN protein images normalized to both the first lane and the β-actin–loading control. *P < 0.005; **P < 0.05.