Figure 1. MHC-II is an important determinant of S. pyogenes nasopharyngeal infection in mice.
(A) Individual mice were nasally inoculated with ∼1×108 bacterial colony forming units (CFU) with MGAS8232 and nasopharyngeal CFUs were assessed at 48 h. Each symbol represents CFUs from an individual mouse. (B) Time-course analysis of MGAS8232 inoculated HLA-B6 mice. CFUs were determined from the cNTs and spleens (n≥3 per group) at the indicated time points. Statistical significance is displayed as **p<0.01 by Student's t-test.