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. 2014 May 29;10(5):e1004155. doi: 10.1371/journal.ppat.1004155

Figure 6. Vaccination with toxoid SAg inhibits S. pyogenes nasopharyngeal infection in mice.

Figure 6

(A) Time-line of vaccination protocol. (B) Anti-SpeA IgG antibody titres (mean ± SEM) from HLA-B6 mice (n = 5 mice per group), either sham vaccinated, or vaccinated with SpeAY100A as described in Materials and Methods. (C) Sham or SpeAY100A vaccinated HLA-B6 mice were nasally inoculated with ∼1×108 bacterial CFUs of S. pyogenes MGAS8232. Nasopharyngeal CFUs were assessed at 48 h. Each symbol represents an individual mouse. Statistical significance is displayed as **p<0.01 by Student's t-test.