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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Nat Neurosci. 2014 Apr 28;17(6):804–806. doi: 10.1038/nn.3710

Fig. 3. Preservation of MeCP2 function in either SOM- or PV-expressing interneurons leads to a partial restoration of auditory processing.

Fig. 3

(a) Heat maps showing changes in event-related power in response to 85-dB white noise sound presentation as a function of time and frequency. (b) Population averages of event-related power for Mecp2Stop/y; PV-Cre (n = 7), Mecp2Stop/y; SOM-Cre (n = 12) and Mecp2Stop/y mice (n = 9). Frequency bands correspond to: δ, 2–4 Hz; θ, 4–8 Hz; α, 8–12 Hz; β, 12–30 Hz; γlow, 30–50 Hz; γhigh, 50–90 Hz; ε, 90–140 Hz. Shaded regions represent s.e.m. Top green or purple bars represent those regions with FDR < 0.05 (permutation test) in SOM- cre or PV-cre mice, respectively. (c) Phenotypic scoring of mice at 12 weeks of age (n = 8 per genotype). *** corresponds to a p-value < 0.001, one-way ANOVA with post hoc Tukey. (d) Survival curves for mice (n = 8 per genotype).