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. Author manuscript; available in PMC: 2014 May 30.
Published in final edited form as: Nat Neurosci. 2010 Jul;13(7):805–811. doi: 10.1038/nn.2575

Figure 2. Cross-talk among macroautophagy and different cellular proteolytic systems.

Figure 2

The consequences of macroautophagic blockage on the activity of other autophagic pathways, endocytosis and on the ubiquitin proteasome system (UPS) and the consequences of changes in these pathways on macroautophagy are depicted. Examples of neurodegenerative disorders for which this crosstalk has been shown to be relevant are indicated in the red boxes and are discussed in more detail in the text. MVB: multivesicular bodies; CMA: chaperone-mediated autophagy; UPS: ubiquitin proteasome system; AD: Alzheimer’s disease; HD: Huntington’s disease; PD: Parkinson’s diease; FTP:frontotemporal dementia; ALS: amyotrophic lateral sclerosis; SMA: spinal muscular atrophy.