TABLE 7. Histological Evaluation of Female and Male PND 21 Mammary Glandsa.
| Treatment | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Negative controls | BPA (μg/kg bw/day) | EE2 (μg/kg bw/day) | |||||||||||
| Naïve | Vehicle | 2.5 | 8 | 25 | 80 | 260 | 840 | 2700 | 100,000 | 300,000 | 0.5 | 5.0 | |
| Females | |||||||||||||
| Duct, hyperplasia | |||||||||||||
| Significance | - | - | - | - | - | - | - | * | ** | - | - | - | |
| Incidence | 2/17 | 0/16 | 2/19 | 1/13 | 4/19 | 1/20 | 1/13 | 2/18 | 5/17 | 6/17 | 3/12 | 0/20 | 1/20 |
| Severity profile | 2/0/0/0 | 0/0/0/0 | 2/0/0/0 | 1/0/0/0 | 4/0/0/0 | 1/0/0/0 | 1/0/0/0 | 2/0/0/0 | 5/0/0/0 | 6/0/0/0 | 3/0/0/0 | - | - |
| Males | |||||||||||||
| Duct, hyperplasia | |||||||||||||
| Significance | - | - | - | - | - | - | - | - | - | - | *** | *** | |
| Incidence | 2/20 | 1/19 | 0/22 | 0/17 | 0/21 | 0/20 | 1/20 | 0/20 | 3/20 | 2/20 | 2/10 | 11/19 | 14/17 |
| Severity profile | 1/1/0/0 | 0/1/0/0 | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | 0/0/0/0 | 1/0/0/0 | 0/0/0/0 | 2/1/0/0 | 2/0/0/0 | 2/0/0/0 | 9/2/0/0 | 1/8/5/0 |
aData are presented as incidence (the number of animals with lesion/the number of animals examined). The severity profile is also shown, i.e, the number of animals with lesions graded as minimal/mild/moderate/marked or grades 1/2/3/4, respectively. Statistical significance based on incidence, or lack thereof, is indicated in the row above the incidence row. A “-“ indicates no significance. *p < 0.05, **p < 0.01, and ***p < 0.001.