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. 2014 Feb 13;139(1):121–132. doi: 10.1093/toxsci/kfu027

FIG. 1.

FIG. 1.

H3S10 phosphorylation is linked to AHR binding at the Cyp1a1 enhancer. The extent of anti-H3S10ph and anti-AHR antibodies binding to the Cyp1a1 enhancer region (from −1.5 to −0.9 kb) was determined by ChIP-qPCR. (A) Hepa-1 cells were treated with B[a]P or control vehicle and binding was determined at 0, 15, 30, and 60 min after treatment. (B) Hepa-1 cells were treated with B[a]P, TCDD, or control DMSO vehicle and binding was determined 90 min after treatment. Statistically significant differences were determined by one-way ANOVA. A p-value <0.05 (*) was considered as significant in comparison to the 0-min time-point (A) or the control DMSO treatment group (B).