Table 2. Genotype distributions and allele frequencies of five examined polymorphisms in STK39 gene between hypertensive patients and normotensive controls.
| Polymorphism* | Patients (n = 1009) | Controls (n = 756) | χ2 | P** | |
|---|---|---|---|---|---|
| rs6749447 | CC | 488 (48.36) | 566 (74.87) | ||
| CA | 435 (43.11) | 175 (23.15) | 132.97 | <0.001 | |
| AA | 86 (8.52) | 15 (1.98) | |||
| A allele | 30.08% | 13.56% | 133.20 | <0.001 | |
| rs12692877 | GG | 710 (70.37) | 531 (70.24) | ||
| GC | 258 (25.57) | 208 (27.51) | 4.95 | 0.084 | |
| CC | 41 (4.06) | 17 (2.25) | |||
| C allele | 16.85% | 16.01% | 0.45 | 0.504 | |
| rs35929607 | AA | 309 (30.26) | 236 (31.22) | ||
| AG | 499 (49.45) | 377 (49.87) | 0.29 | 0.866 | |
| GG | 201 (19.92) | 143 (18.92) | |||
| G allele | 44.65% | 43.85% | 0.22 | 0.636 | |
| rs3754777 | GG | 562 (55.70) | 629 (83.20) | ||
| GA | 384 (38.06) | 119 (15.74) | 152.86 | <0.001 | |
| AA | 63 (6.24) | 8 (1.06) | |||
| A allele | 25.27% | 8.93% | 154.62 | <0.001 | |
| rs6433027 | CC | 178 (17.64) | 212 (28.04) | ||
| CT | 490 (48.56) | 358 (47.35) | 33.52 | <0.001 | |
| TT | 341 (33.80) | 186 (24.60) | |||
| T allele | 58.08% | 48.28% | 33.39 | <0.001 | |
*Genotypes of five examined polymorphisms were expressed as count (percentage).
**P values were computed by using the χ2 test based on the 3 × 2 contingency tables for the genotype comparison and on the 2 × 2 contingency tables for the allele comparison.