Table 4. Frequencies of derived haplotypes (≥1% in total subjects) from five examined polymorphisms in STK39 gene between hypertensive patients and normotensive controls.
Haplotype (%)* | Total (n = 1765) | Patients (n = 1009) | Controls (n = 756) | Simulated P |
---|---|---|---|---|
C-G-A-G-T | 13.18 | 15.68 | 11.70 | <0.001 |
C-G-G-G-T | 12.27 | 14.59 | 10.98 | 0.001 |
C-G-A-G-C | 12.14 | 20.67 | 5.34 | <0.001 |
C-G-G-G-C | 11.45 | 14.38 | 8.90 | <0.001 |
A-G-G-G-T | 8.36 | 3.13 | 11.70 | <0.001 |
C-G-A-A-C | 8.07 | 1.78 | 13.03 | <0.001 |
C-G-A-A-T | 6.23 | 2.76 | 8.21 | <0.001 |
A-G-G-G-C | 4.31 | 3.14 | 5.45 | <0.001 |
A-G-A-G-T | 4.08 | 2.55 | 5.38 | <0.001 |
C-C-A-G-T | 3.49 | 4.76 | 2.97 | 0.001 |
C-C-G-G-C | 2.64 | 2.70 | 2.74 | 0.115 |
A-G-A-G-C | 2.38 | 2.33 | 2.47 | 0.393 |
C-C-A-G-C | 1.97 | 3.60 | 0.33 | <0.001 |
A-C-G-G-T | 1.80 | 0.73 | 2.57 | <0.001 |
C-C-G-G-T | 1.68 | 1.57 | 1.69 | 0.460 |
C-C-A-A-C | 1.40 | 0.27 | 2.45 | <0.001 |
C-C-A-A-T | 1.32 | 0.54 | 1.58 | <0.001 |
*Alleles in a haplotype were in order of rs6749447, rs12692877, rs35929607, rs3754777 and rs6433027 in STK39 gene.