Figure 1. SETD2 is necessary for ATM activation during the DNA damage response.
Control and SETD2 RNAi-depleted U2OS cells were challenged with etoposide (A), NCS (B) or phleomycin (C) and chased in fresh media during the indicated time points. Western blot analysis was performed with antibodies against the indicated proteins. Molecular weight markers (KDa) are shown on the left of each blot. Data are from one representative experiment of at least three independent experiments performed with similar results.