Table 2.

ACTH and Cortisol (mean ± SD) Pulsatile Characteristics as Determined by Smoothing Baseline Pulse Pulses (SBPP) Analysis and Mean ACTH and Cortisol Concentrations Over 12 Hours (2000 to 0800 Hour) and in 3-Hour Blocks. See Text for Description of SBPP Measures.

	Healthy controls	Alcohol-dependent	T-stat	df	p Value	Effect size
ACTH pulsatile characteristics
Total probability	20.3 ± 12.5	13.0 ± 12.4	1.05	12	0.32	0.6
Adjusted input	138.7 ± 81.8	100.2 ± 96.1	0.76	12	0.47	0.4
Number of inputs	17.5 ± 13.7	12.4 ± 11.6	0.74	12	0.47	0.4
Average baseline	14.6 ± 4.2	20.5 ± 9.3	−1.34	12	0.24	0.9
Mean amplitude	7.0 ± 3.6	9.3 ± 3.5	−1.15	12	0.28	0.7
Mean ACTH concentrations (pg/ml)
2000–2300 hour	14.0 ± 4.8	15.8 ± 5.7	−0.75	14	0.46
2300–0200 hour	17.6 ± 5.4	19.4 ± 8.7	−0.50	14	0.63
0200–0500 hour	24.5 ± 3.2	27.0 ± 9.3	−0.68	14	0.52
0500–0800 hour	29.9 ± 5.8	32.8 ± 9.2	−0.77	14	0.46
Cortisol pulsatile characteristics
Total probability	14.1 ± 6.7	16.3 ± 8.0	−0.58	14	0.57	0.3
Adjusted input	36.7 ± 14.3	33.3 ± 11.4	0.74	14	0.61	0.3
Number of inputs	12.7 ± 5.7	14.1 ± 6.5	−0.44	14	0.67	0.2
Average baseline	2.3 ± 1.8	2.0 ± 1.3	0.38	14	0.71	0.2
Mean amplitude	3.0 ± 1.2	2.3 ± 1.0	1.35	14	0.20	0.6
Mean cortisol concentrations (μg/dl)
2000–2300 hour	2.6 ± 1.1	2.5 ± 1.1	0.31	14	0.76
2300–0200 hour	3.5 ± 2.3	2.3 ± 0.9	1.40	14	0.19
0200–0500 hour	7.7 ± 1.7	5.9 ± 2.1	1.93	14	0.07
0500–0800 hour	11.4 ± 1.4	10.1 ± 2.7	1.33	14	0.21