Table 2. Mediation analyses in the InterAct subcohort participants with full availability of mediators.
| Subcohort onlya (N=4,154; 154 Cases) | ||||
|---|---|---|---|---|
| Mediator | Total Effect (TE) | Direct Effect (DE) | Indirect effect (IE) | Proportion Mediated (%) ((ln(IE)/ln(TE)) |
| BMI | 2.92 (2.02, 4.11) | 2.72 (1.9, 3.88) | 1.15 (1.08, 1.22) | 12.7 (6.8, 18.6) |
| Waist Circumference | 2.92 (2.02, 4.11) | 2.65 (1.85, 3.8) | 1.17 (1.09, 1.26) | 14.9 (8.4, 21.3) |
| Hip circumference | 2.92 (2.02, 4.11) | 2.77 (1.95, 3.93) | 1.11 (1.05, 1.17) | 9.7 (4.8, 14.6) |
| Education Level | 2.92 (2.02, 4.11) | 2.89 (2.05, 4.07) | 1.02 (1, 1.04) | 1.8 (−0.2, 3.9) |
| Genetic risk score | 2.92 (2.02, 4.11) | 2.88 (2.04, 4.06) | 1.02 (1, 1.04) | 1.9 (−0.2, 4) |
| Physical activity index | 2.92 (2.02, 4.11) | 2.93 (2.08, 4.13) | 1 (0.99, 1.01) | −0.2 (−1.2, 0.6) |
| Mediterranean diet pattern | 2.92 (2.02, 4.11) | 2.92 (2.07, 4.12) | 1 (1, 1) | 0 (−0.1, 0.1) |
| Smoking | 2.92 (2.02, 4.11) | 2.95 (2.09, 4.16) | 0.99 (0.97, 1.01) | −0.1 (−2.5, 0.5) |
|
| ||||
| All of the above | 2.92 (2.02, 4.11) | 2.65 (1.84, 3.81) | 1.19 | 16.16 |
TE shows the association between family history and incident diabetes unadjusted for any mediators. DE is the direct effect of family history independent of the specified mediators, while IE is the indirect effect of family history via the specified mediator.
a
Analyses were performed in the subcohort only using logistic regression to model the log odds of being a case, adjusted for age, sex and centre of recruitment and restricted to individuals with full availability of mediators