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. 2014 May 30;6:100. doi: 10.3389/fnagi.2014.00100

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Copyright © 2014 Chen, Run, Liang, Zhao, Dai, Iqbal, Liu and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tau hyperphosphorylation at various AD-related sites in the brains of 3xTg-AD mice after anesthesia with propofol. (A) Homogenates of the rostral halves of brains from 3xTg-AD mice sacrificed 30 min or 2 h following intraperitoneal injection of propofol were analyzed by Western blots developed with antibody R134d against total tau and several phosphorylation-dependent and site-specific tau antibodies, as indicated in the middle of the blots. (B,C) Densitometrical quantifications (mean ± SEM, n = 6/group) of the blots after being normalized with the corresponding total tau level (B) or with the GAPDH level (C). The levels of the 3xTg-veh1/veh2 group were set to 100. *p < 0.05 vs. vehicle-injected 3xTg-AD mice.