Table 4.
Genetic markers associated with antidepressant response
| Drug/Phenotype | Gene | Marker | Subjects | Studies | Diagnosis | Phenotype association | Level of evidence |
|---|---|---|---|---|---|---|---|
| Antidepressant | GRIK4 |
rs1954787 |
1,816 |
2 |
MDD |
CC genotype associated with better citalopram response |
1 |
| HTR2A |
rs7997012 |
1,329 |
1 |
MDD |
A-allele associated with better citalopram response |
1 |
|
| SLC6A4 |
5-HTTLPR |
1,435 |
15 |
MDD, BD |
long allele associated with better SSRI response, short allele increases risk of AIM |
1 |
|
| FKBP5 |
rs4713916 |
1,426 |
4 |
MDD, BD, dysthymia |
A-allele associated with better antidepressant response |
1 |
|
| ABCB1 | rs2032583, rs2235040 | 689 |
2 |
MDD |
C and A alleles respectively associated with better response |
1 |
|
| 424 | 1 | MDD | C and A alleles respectively associated with adverse effects | 2 |
AIM, antidepressant induced mania; BD, bipolar disorder; MDD, major depression; SSRI, selective serotonin receptor inhibitor.