Table 4.
Correlation between miR-143 expression and cervical SCC clinical pathological features
| Clinical characters | Cases (n) | miR-143 expression | Z | P |
|---|---|---|---|---|
|
Cervical SCC |
|
|
−2.180 |
0.029* |
| No |
20 |
1.000 (0.241-1.878) |
|
|
| Yes |
77 |
0.280 (0.059-1.050) |
|
|
|
Age (years old) |
|
|
−1.236 |
0.217 |
| ≤ 50 |
41 |
0.259 (0.143-0.707) |
|
|
| > 50 |
36 |
0.337 (0.167-1.092) |
|
|
|
Clinical Stage |
|
|
2.673 |
0.263 |
| I |
16 |
0.387 (0.176-1.258) |
|
|
| II |
43 |
0.268 (0.131-0.698) |
|
|
| III-IV |
18 |
0.287 (0.155-0.905) |
|
|
|
Pathological Grade |
|
|
−1.142 |
0.253 |
| Well differentiation |
27 |
0.320 (0.198-0.859) |
|
|
| Moderate and poor differentiation |
50 |
0.258 (0.118-1.052) |
|
|
|
Lymph node metastasis |
|
|
−2.293 |
0.022* |
| No |
43 |
0.578 (0.209-1.384) |
|
|
| Yes |
16 |
0.175 (0.103-0.544) |
|
|
|
Tumor diameter |
|
|
−2.705 |
0.007* |
| ≤ 4 cm (smaller tumor) |
54 |
0.345 (0.112-1.490) |
|
|
| > 4 cm (larger tumor) |
23 |
0.125 (0.103-0.459) |
|
|
|
LVSI |
|
|
−0.567 |
0.571 |
| No |
46 |
0.294 (0.159-1.075) |
|
|
| Yes |
13 |
0.607 (0.293-1.501) |
|
|
|
HPV infection |
|
|
9.050 |
0.011* |
| HPV negative |
17 |
1.053 (0.289-1.412) |
|
|
| HPV16 infection (single or multiple)△ |
32 |
0.230 (0.105-0.496) |
−2.647 |
0.008* |
| Other genotype HPV infection△ | 28 | 0.524 (0.109-1.233) | −1.651 | 0.099 |
Note: *P < 0.05. △in comparison with HPV negative group.
SCC, squamous cell carcinoma; LVSI, lymph vascular space invasion.